Michele A. Kliem, PhD

Patent Agent

kliemm@ballardspahr.com
Tel 678.420.9560
Fax 678.420.9301
Atlanta

Michele A. Kliem is an experienced patent agent and a member of the biotechnology and pharmaceutical practice teams in Ballard Spahr's Patents Group. Michele drafts and prosecutes patent applications in the biological and pharmaceutical arts, including immunology, biotechnology, drug delivery systems, life sciences, pharmaceuticals, neuroscience, drug formulations, genetics, molecular biology and medical devices. She also prepares infringement and validity analyses, and assists with litigation, pre-litigation strategic planning, and the filing of Abbreviated New Drug Applications and notice letters.

Michele's previous research encompasses the neuronal recording of brain electrical circuits, intracerebral drug injections, spinal cord viral vector injections, microdialysis, electron microscopy, immunocytochemistry, immunohistochemistry, and immunofluorescence.

As part of her doctoral research in the Molecular and Systems Pharmacology Program at Emory University, she developed a novel combination nerve cell recording-drug injection delivery system and conducted pharmacological studies on the effects of dopamine receptor drugs on the electrical activity of nerve cells involved in motor, cognitive, and limbic functions. She also conducted immunocytochemical studies on the effects of dopamine loss using receptor-specific antibodies to quantify ultrastructural dopamine receptor changes involved in motor, cognitive, and limbic brain circuits. As a Post-Doctoral Fellow in the Department of Neurosurgery Emory University, she applied gene therapy technology to assess disease symptoms in a rate model of amyotrophic lateral sclerosis.

Michele previously worked as a pharmacologist at Eli Lilly in Indianapolis and as a senior research specialist at Emory University's Yerkes National Primate Research Center, where she managed a primate behavioral/electrophysiology/pharmacology lab.

Professional Activities

Society for Neuroscience

International Basal Ganglia Society

Instructor, Georgia Institute of Technology, Department of Applied Physiology, 2010-present

Publications

Michele has co-authored numerous scientific publications, including:

"Addressing Breach of Method-of-Use Patents by Generics," Law360, May 2, 2012

"Assessment of Hippocampal Adena-associated Viral Vector Gene Delivery via Frarneless Stereotaxis in a Nonhuman Primate," Stereotactic Functional Neurosurgery, 89(5):275-85, 2011

"Intramuscular Administration of a VEGF Zinc Finger Transcription Factor Activator (VEGF-ZFP-TF) Improves Functional Outcomes in SOD1 Rats," Amyotrophic Lateral Sclerosis, 12(5):331-9, 2011

"Ultrastructural Localization and Function of Dopamine Dl-Like Receptors in the Substantia Nigra Pars Reticulata and the Internal Segment of the Globus Pallidus of Parkinsonian Monkeys," European Journal of Neuroscience, 31 :836-851, 2010

"Basal Ganglia: Functional Models of Normal and Disease States," in: Squire L.R. (ed.) Encyclopedia for Neuroscience, Volume 2, Oxford: Academic Press, 2009

"Basal Ganglia: Functional Models of Normal and Disease States," in: Handbook of the Neuroscience of Aging, ed. Patrick R. Hof and Charles V. Mobbs, San Diego: Academic Press, 2009

"A Conditioning Lesion is Protective in a Model of Amyotrophic Lateral Sclerosis," PLoS ONE, 4(10): e7357, 2009

"Comparative Ultrastructural Analysis of DI and D5 Dopamine Receptor Distribution in the Substantia Nigra and Globus Pallidus of Monkeys," The Basal Ganglia IX, editors Berendse, Cools, Voorn and Mulder, 2008

"Activation of Nigral and Pallidal Dopamine D1-Like Receptors Modulates Basal Ganglia Outflow in Monkeys," Journal of Neurophysiology, 98:1489-1500, 2007

"Gabergic and Dopaminergic Modulation of Basal Ganglia Output in Primates," The Basal Ganglia VIII, editors Bolam, Magill and Ingram, 2005

"Neuronal Activity in the Primate Substantia Nigra Pars Reticulata During the Performance of Simple and Memory-Guided Elbow Movements," Journal of Neurophysiology, 91:815-827, 2004

"Role of External Pallidal Segment in Primate Parkinsonism: Comparison of the Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinsonism and Lesions of the External Pallidal Segment," Journal of Neuroscience, 24(29):6417-6426, 2004

"A Method to Record Changes in Local Neuronal Discharge in Response to Infusion of Small Drug Quantities in Awake Monkeys," Journal of Neuroscience Methods, 138:45-49, 2004

Emory University (Ph.D. 2008, pharmacology)

University of Toledo (M.S. 1994, pharmacology)

Ashland University (B.S. 1992, biology)
Honors Program; Recipient, Presidential Scholarship, Ohio Choice Grant, and H. Gehman Chemistry Scholarship

U.S. Patent and Trademark Office